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The FAME study was designed to reflect daily practice in performing PCI in patients with multivessel disease
Inclusion criteria:
- ALL patients with multivessel disease
- At least 2 stenoses greater or equal to 50% in 2 or 3 major epicardial coronary artery disease, amenable for stenting
Exclusion criteria:
- Left main disease or previous bypass surgery
- ST-elevation MI with CK greater then 1000 U/l within last 5 days
- extremely tortuous or calcified coronary arteries
Note: patients with previous PCI were not excluded
PRIMARY ENDPOINT
Composite of death, myocardial infarction, or repeat revascularization (“MACE”) at 1 year
SECONDARY ENDPOINTS
- individual components of MACE at 1 year
- functional class
- use of anti-anginal drugs
- health-related quality of life (EuroQOL-5D)
- procedure time
- amount of contrast agent used during procedure
- cost of the procedure
FAME study design and purpose:
FAME Study Investigators.Rationale and design of the Fractional Flow Reserve versus Angiography for Multivessel Evaluation (FAME) study.
William F. Fearon, et al. Am Heart J. 2007 Oct;154(4):632-6. Erratum in: Am Heart J. 2007 Dec;154(6):1243.
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